Mitochondrial Donation Program

Assisted reproductive treatments aim to facilitate pregnancy but often encounter challenges due to poor egg quality, primarily influenced by defective mitochondria. To address this, mitochondrial donation emerges as an innovative solution, allowing individuals struggling with mitochondrial issues to fulfill their dream of parenthood while preserving their genetic lineage.

Method and Process

Mitochondrial Exchange: This technique involves transferring nuclear DNA from an individual’s egg, containing defective mitochondria, into a donor egg devoid of nuclear DNA. The process, conducted pre-fertilization (maternal spindle transfer) or post-fertilization (pronuclear transfer), results in a fertilized egg transferred into the mother’s uterus using standard IVF practices.

Suitable Candidates

For Those with Poor Egg Quality: Individuals facing challenges with embryo development due to poor egg quality find conventional egg donation programs inadequate. Mitochondrial degeneration negatively impacts pregnancy success rates, especially with aging eggs, leading to reduced energy and compromised fertilization. Mitochondrial donation techniques offer hope for those struggling with mitochondrial issues, enabling the restoration of healthy nuclear function within the oocyte.

Pronuclear Donation Program

Enhanced IVF: The pronuclear embryo transfer involves utilizing eggs with mutated DNA-containing mitochondria from the woman and sperm from the intended father. On day 1 of development, pronuclei, housing most of the mutated mitochondria, are extracted and transferred into an enucleated zygote carrying healthy mitochondria.

Advantages

Mitigation of Mitochondrial Diseases: Pronuclear transfer minimizes the risk of fertilization and provides families affected by severe mitochondrial diseases an opportunity to conceive healthy children, free from debilitating conditions. This approach offers promising blastocyst outcomes and serves as a final recourse for individuals previously considered only for oocyte donation, granting them a chance at a genetically healthy child.

Stem&Gene ART Clinic supplies many treatment options for the IVF process. IVF concept require high level of embryology laboratory standards. For increasing reproductive income and high pregnancy rate embryo quality is the key point. We are using different stimulation protocol options for our patients according their availability and reproductive conditions. You will find flexible stimulation protocols which will allow you manage your trips and work life same time during your IVF treatments. Our IVF laboratory offers you different techniques which will increase your embryo outcome and pregnancy chance. Our lab director and lab supervisor analyze each cycle and all previous attempts and consult with you for alternative laboratory process. Your bio-materials always under safety instruction for electronic witness sytem and lab tracking systems. You will find totally transperant information and daily reporting regarding your IVF journey and laboratory process. The IVF Laboratory will supply you fully reporting with explanation, images and videos for your biological material and laboratory outcome. During your fertilisation and embryo transfer process you will have chance to follow up from the screens your process as live video option. We believe that our expertise together with technology and transperancy will bring success and you will feel confident and happy regarding your IVF treatment.