Preimplantation genetic testing (PGT) offers a pivotal option for individuals with a family history of inherited diseases. It’s a screening method performed on embryos developed through in vitro fertilization (IVF) to analyze genetic characteristics before their transfer.

The Role of PGT

• Preventing Genetic Diseases: PGT enables the detection of abnormal embryo genetics, significantly reducing the risk of inherited diseases in offspring.
• Ensuring Chromosomal Integrity: By confirming the correct chromosome count in selected embryos, PGT minimizes the chances of failed IVF cycles and reduces the risk of miscarriage.

Ideal Candidates for PGT

• Women Over 37: Due to increased risks associated with normal reproductive aging.
• Couples with Genetic Risks: Those with a potential risk of passing on inherited genetic diseases.
• History of Recurrent Miscarriages: In cases attributed to chromosomal abnormalities.

Conducting PGT

• IVF Procedure: The first step involves IVF to produce embryos for PGT.
• Embryo Cell Sampling: After egg retrieval and laboratory fertilization, assisted hatching is performed for cell sampling.
• Genetic Analysis: Cells from the outer layer of the embryo are biopsied at the blastocyst stage for subsequent genetic analysis.

Preimplantation genetic screening serves as a proactive measure in ensuring healthier pregnancies by assessing embryos for genetic abnormalities. It offers hope to individuals with familial genetic concerns, allowing for a higher likelihood of successful pregnancies while mitigating the risk of transmitting inherited diseases.